Biosynthesis of Chondroitin Sulfate Proteoglycan
نویسندگان
چکیده
منابع مشابه
Biosynthesis of Chondroitin Sulfate
A microsomal preparation from chick embryo cartilage has been shown to catalyze the incorporation of sulfate-36S from 3’-phosphoadenosine 5’-phosphosulfate-3% into microsomal glycosaminoglycan. This enzyme preparation is the same preparation that previously has been shown to catalyze the formation of chondroitin (nonsulfated) from sugar nucleotide precursors. The microsomal sulfate acceptor app...
متن کاملBiosynthesis of Chondroitin Sulfate
The role of phospholipids in the activity of UDP-D-galactose:D-xylose galactosyltransferase (galactosyltransferase I) from embryonic chick cartilage was investigated. Phospholipase C treatment of particulate galactosyltransferase I caused inactivation of this enzyme to the extent of 60 to 70% as well as hydrolysis of 75 to 80% of the membrane phospholipids. Addition of phospholipid restored act...
متن کاملBiosynthesis of chondroitin sulfate proteoglycan by P388D1 macrophage-like cell line.
Macrophages are in large part responsible for the subendothelial deposition of lipid within the artery wall during the early stages of atherogenesis. Proteoglycans secreted by these cells may play a role in this pathological process either by trapping lipoproteins in the extracellular matrix or by enhancing the formation of lipid-laden foam cells. The synthesis and secretion of proteoglycan was...
متن کاملBiosynthesis of Chondroitin Sulfate Proteoglycan by P388D! Macrophage-like Cell Line
Macrophages are In large part responsible for the subendothellal deposition of llpld within the artery wall during the early stages of atherogenesls. Proteoglycans secreted by these cells may play a role In this pathological process either by trapping llpoprotelns In the extracellular matrix or by enhancing the formation of llpld-laden foam cells. The synthesis and secretion of proteoglycan was...
متن کاملBiosynthesis of chondroitin sulfate. Organization of sulfation.
The potential relationship of an intact membrane organization for the synthesis of chondroitin and chondroitin 4-sulfate was examined after modification of a mouse mast cell microsomal system with the nonionic detergent, Triton X-100. The results indicated that Triton X-100 had no effect on the rate of polymerization but had a slight effect on the size of glycosaminoglycan chains. An "all or no...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1972
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)45110-7